The project topic refers to development of innovative methods for osseointegrative biofunctionalisation of new titanium bioalloy surface. The necessity for long term implantation success requires surface coatings with bioactivity, osseoconductivity and strong adhesion to the metallic substrate. Project approaches these three demands by the surface hydroprocessing, obtaining the alloy surface architecturing by electrochemical (for adhesion), chemical (for bioactivity) and biomimetic (for biomimetism) methods. The originality and innovations of the project objectives are: advanced electrochemical procedure (with optimized parameters) for the primary adherent layer; biofunctionalisation by the chemical deposition (adapted innovative method) for the secondary layer; biomimetic chemical deposition of the osseoconductive factor; obtaining of multi-layer coating with tailored properties, which simultaneously exhibit controlled biomolecule release and bioactive behaviour; modeling of the biomimetic coating / simulated biofluids interface by modern electrochemical methods; monitoring of the coating stability using high level electrochemical, microscopic and spectroscopic techniques. The project will contribute to enhance the world level of knowledge in the high interest field of advanced implant biomaterials with improved osseointegration. The original results will impact the scientific national and international community by: 1 patent proposal, 4 communications, 4 scientific papers.
DEVELOPMENT OF INNOVATIVE METHODS FOR OSSEOINTEGRATIVE BIOFUNCTIONALIZATION OF NEW TITANIUM BIOALLOYS SURFACES
