WP number: 1
WP title: International trends regarding the most recent advanced titanium bioalloys; worldwide problematic concerning the controlled processing of the titanium alloys surface for functionalisation. Elaboration of methods for bioalloy synthesis, thermo mechanical treatment, surface functionalisation, implant execution. Characterisation methods. Preliminary experiments
Leader: ICF
Partners involved: ICF, R&D, TMI, JSI, UP
Objectives: Research of problematic in domain
(Milestones) Elaboration of methods for: bioalloy synthesis and thermo mechanical processing, surface functionalisation; implant execution
Selection of characterisation methods
Expected results: Data base on composition of new bioalloy and on surface functionalisation
Implant geometry and execution methods
Non-polluting methods for obtaining the bioalloy and thermo-mechanical processing
Characterisation methods (chemical, structural, mechanical, biocompatibility)
Deliverables: Research report
WP number: 2
WP title: Elaboration of the vacuum technology for obtaining of the new, non-toxic, innovative bioalloy. Application of the special thermo-mechanical treatments. Samples for the experiments of the new methodologies for controlled surface structuring. Chemical, structural and mechanical characterisation of the new bioalloy; electrochemical behaviour of the bioalloy / SBF interface; in vitro determination of the biocompatibility (innovative researches)
Leader: R&D
Partners involved: ICF, R&D, JSI, UP
Objectives: Formulation of bioalloy composition
(Milestones) Design of synthesis and thermo-mechanical processing technologies
Electrochemical behaviour of new bioalloy
In vitro biocompatibility
Expected results: Bioalloy composition
Process parameters for: bioalloy synthesis and thermo-mechanical processing
Biochemical and biomechanical compatibility of the new bioalloy
Proof the lack of allergic and toxic reactions
Deliverables: Research report. Analysis report
WP number: 3
WP title: Controlled surface functionalisation of the alloy by electrochemical methods; characterisation of the processed surface; modelling of the bioalloy with modified surface/SBF interface and analysis of the cell adhesion and proliferation (scientific novelties)
Leader: ICF
Partners involved: ICF, JSI, UP
Objectives: Design of controlled surface structuring by electrochemical method
(Milestones) Structural and electrochemical characterisation of processed surface
Analysis of cell culture
Expected results: Laboratory flux for controlled surface structuring by electrochemical method
Processing parameters for surface electrochemical functionalisation
Complex and complete characterisation of structured surface
Deliverables: Research report. Analysis report
WP number: 4
WP title: Surface functionalisation by green chemical methods; evaluation of the new surface structure and properties; establishment of the processes at the interface, of the protective capacity and of the biocompatibility of the new chemical coating (original contributions
Leader: ICF
Partners involved: ICF, JSI, UP
Objectives: Design of surface functionalisation by green chemical methods
(Milestones) Evaluation of main characteristics of new chemical coating
Evaluation of coating protective capacity and its biocompatibility
Expected results: Laboratory flux for chemical surface functionalisation
Increase of the alloy biocompatibility and bioactivity.
Establishment of the original physical models
Rapid methods for the predictable information about the behaviour of new covered alloy
Deliverables: Research report. Analysis report
WP number: 5
WP title: Selection of the optimum surface functionalisation method for the implant specific destination; modelling, design and experiments for implant manufacture using new advanced bioalloy with modified bioactive surfaces
Leader: ICF
Partners involved: ICF, R&D, TMI, JSI, UP
Objectives: Critical evaluation of the alloy with bioactive surface properties
(Milestones) Analysis of surface functionalisation methods and selection of the optimum implants
Design, modelling and experiments for implant manufacture
Expected results: Comparative analysis
Establishment of optimum surface functionalisation method
Implant execution technology design
Deliverables: Research report
WP number: 6
WP title: Demonstration of technologies for bioalloy synthesis and thermo mechanical processing. Demonstration of technologies for obtaining of orthopaedic implant with functionalised surface and high biocompatibility. Test lot. Elaboration of the documentation for technology transfer and industrial application
Leader: ICF
Partners involved: ICF, R&D, TMI, JSI, UP
Objectives: Reproducibility of technologies parameters for: bioalloy synthesis and thermo mechanical processing, implant execution and
surface functionalisation
(Milestones) Realisation of test lot (bioalloy and orthopaedic implants with functionalised surface)
Demonstration of the un- and covered bioalloy stability, functionality and biocompatibility
Evaluation of technical - economic impact
Realization of technical specifications and technology transfer
Program for industrial implementation
Patents elaboration
Expected results: Demonstrated technologies for: bioalloy synthesis and thermo mechanical processing, implant execution and surface
functionalisation
Test lot characterised
Original data bank for the users of the alloys with active surfaces
Technical economic analysis report
Technical specifications for industrial application
Implementation program for implant certification, production and commercialisation
Technology transfer documents
2 patents
commercialisation. 2 patents registration document. Project final report