The development (using new environmentally friendly methods-high vacuum melting), of new advanced, complex and innovative bioalloy (original composition) for orthopaedic implants based on non toxic elements, with high added value due to the increased resistance to corrosion, very good biocompatibility and improved mechanical properties in order to assure the excellent performance and reliability during an extended working lifetime, with beneficial effects for the quality of life and comfort of the patients and the innovative implant commercialization
The controlled application of treatments for surface structuring and functionalisation (scientific novelties) using non-polluting and non-toxic chemical solution and electrochemical methods for the obtaining of nanoporous structures, with increased bioactivity, osseointegration ability, very long life time and development of bone cells on the implants manufactured from the new bioalloy.
The development of new preparation technologies for the obtaining of the bioalloy and of its surface functionalisation using green solution chemistry and electrochemistry.
The complete and complex evaluation of the structural and functional characteristics (scientific novelties) correlated to the increase of the bioactivity.
Multi and interdisciplinary original researches oriented towards the knowledge of the phenomena and mechanisms converging to the obtaining of advanced biomaterials (not obtained till present), which permit the process control from the biomaterial/tissue interface for the stimulation of the cell growth.
Test lot of the new alloy with functionalised surface, technology transfer and industrial implementation planning to generate a new, competitive, innovative European product for a rapidly growing world market.
- Research of international trends regarding new functionalities of the most recent advanced Ti bioalloys.
- Study of the worldwide problems concerning controlled modification of the surfaces of Ti-based alloys.
- Elaborate of the vacuum, non-polluting technology for synthesis of the new bioalloy with advanced biological properties, using compositional design.
- Improvement of mechanical properties of the new bioalloys by special thermo-mechanical processing to obtain a nanocrystalline functional structure by controlled surface treatments.
- Compositional and structural characterisation of the new, innovative bioalloy (for the first time). Electrochemical behaviour of the interfaces: bioalloy/simulated body fluids (scientific novelty).
- In vitro determination (for the first time) of the biocompatibility of the new bioalloy.
- Elaboration of new methodologies for the controlled modification of the surface functionalisation with the aim of the increase of the cell adhesion and bioactivity.
- Characterisation of the processed surfaces using high level, modern methods (original results).
- Electrochemical characterisation of the bioactive alloy/SBF interfaces (original research).
- In vitro biocompatibility determination of the alloy with surface functionalisation (original results).
- Determination of bioalloy behaviour in extreme functional conditions with prognosis of its resistance.
- Selection of the optimum methods for the orthopaedic implants.
- Study regarding types and dimensions of orthopaedic implants. Selection of the implant models.
- Design, modelling and experiments for implant manufacture.
- Tests for checking the reproducibility of technologies parameters: synthesis, thermo-mechanical processing, implant execution, surface functionalisation.
- Demonstration of new processed surface bioalloy stability, functionality and biocompatibility.
- Technical-economic analysis.
- Technology transfer and industrial implementation planning.
-The improvement of the life quality of the patients which will utilise the new advanced alloy by better health conditions by the replacement of the risky materials with new high biocompatible alloys. Using high vacuum and green chemistry technologies will contribute to a durable development. The new alloys, being very resistant is expected to have a very long life time (more 20 years) and will thus improve the efficiency of the use of the material resources.